Longitudinal phenotype development in a minipig model of neurofibromatosis type 1

Neurofibromatosis type 1 (NF1) is a rare, autosomal dominant disease with variable clinical presentations. Large animal models are useful to help dissect molecular mechanisms, determine relevant biomarkers, and develop effective therapeutics. Here, we studied a NF1 minipig model (NF1(+/ex42del)) for...

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Vydáno v:Sci Rep
Hlavní autoři: Uthoff, Johanna, Larson, Jared, Sato, Takashi S., Hammond, Emily, Schroeder, Kimberly E., Rohret, Frank, Rogers, Christopher S., Quelle, Dawn E., Darbro, Benjamin W., Khanna, Rajesh, Weimer, Jill M., Meyerholz, David K., Sieren, Jessica C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081358/
https://ncbi.nlm.nih.gov/pubmed/32193437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61251-4
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