Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell–Derived Cerebral Organoids in Schizophrenia

IMPORTANCE: Three-dimensional cerebral organoids generated from patient-derived induced pluripotent stem cells (iPSCs) may be used to interrogate cellular-molecular underpinnings of schizophrenia. OBJECTIVE: To determine transcriptomic profiles and functional characteristics of cerebral organoids fr...

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Publicado en:JAMA Psychiatry
Autores principales: Kathuria, Annie, Lopez-Lengowski, Kara, Jagtap, Smita S., McPhie, Donna, Perlis, Roy H., Cohen, Bruce M., Karmacharya, Rakesh
Formato: Artigo
Lenguaje:Inglês
Publicado: American Medical Association 2020
Materias:
Original Investigation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081156/
https://ncbi.nlm.nih.gov/pubmed/32186681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamapsychiatry.2020.0196
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