Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness

Drug resistance remains a serious issue of clinical importance and is a consequence of cancer stemness. In this study, we showed that the level of Aldolase A (ALDOA) expression is significantly associated with the IC50 value of chemotherapy drugs in lung cancer. Our data revealed that ALDOA overexpr...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Chang, Yu-Chan, Yang, Yi-Fang, Chiou, Jean, Tsai, Hsing-Fang, Fang, Chih-Yeu, Yang, Chih-Jen, Chen, Chi-Long, Hsiao, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080828/
https://ncbi.nlm.nih.gov/pubmed/32188842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2387-2
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