RAB5A and TRAPPC6B are novel targets for Shiga toxin 2a inactivation in kidney epithelial cells

The cardinal virulence factor of human-pathogenic enterohaemorrhagic Escherichia coli (EHEC) is Shiga toxin (Stx), which causes severe extraintestinal complications including kidney failure by damaging renal endothelial cells. In EHEC pathogenesis, the disturbance of the kidney epithelium by Stx bec...

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Published in:Sci Rep
Main Authors: Kouzel, Ivan U., Kehl, Alexander, Berger, Petya, Liashkovich, Ivan, Steil, Daniel, Makalowski, Wojciech, Suzuki, Yutaka, Pohlentz, Gottfried, Karch, Helge, Mellmann, Alexander, Müthing, Johannes
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080763/
https://ncbi.nlm.nih.gov/pubmed/32188865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59694-w
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