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A response‐adaptive randomization procedure for multi‐armed clinical trials with normally distributed outcomes

We propose a novel response‐adaptive randomization procedure for multi‐armed trials with continuous outcomes that are assumed to be normally distributed. Our proposed rule is non‐myopic, and oriented toward a patient benefit objective, yet maintains computational feasibility. We derive our response‐...

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Detalhes bibliográficos
Publicado no:Biometrics
Main Authors: Williamson, S. Faye, Villar, Sofía S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078926/
https://ncbi.nlm.nih.gov/pubmed/31322732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/biom.13119
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