A Solution to Antifolate Resistance in Group B Streptococcus: Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim

Adjuvants can be used to potentiate the function of antibiotics whose efficacy has been reduced by acquired or intrinsic resistance. In the present study, we discovered that human milk oligosaccharides (HMOs) sensitize strains of group B Streptococcus (GBS) to trimethoprim (TMP), an antibiotic to wh...

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Pubblicato in:mBio
Autori principali: Chambers, Schuyler A., Moore, Rebecca E., Craft, Kelly M., Thomas, Harrison C., Das, Rishub, Manning, Shannon D., Codreanu, Simona G., Sherrod, Stacy D., Aronoff, David M., McLean, John A., Gaddy, Jennifer A., Townsend, Steven D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078465/
https://ncbi.nlm.nih.gov/pubmed/32184236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00076-20
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