A Solution to Antifolate Resistance in Group B Streptococcus: Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim

Adjuvants can be used to potentiate the function of antibiotics whose efficacy has been reduced by acquired or intrinsic resistance. In the present study, we discovered that human milk oligosaccharides (HMOs) sensitize strains of group B Streptococcus (GBS) to trimethoprim (TMP), an antibiotic to wh...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Chambers, Schuyler A., Moore, Rebecca E., Craft, Kelly M., Thomas, Harrison C., Das, Rishub, Manning, Shannon D., Codreanu, Simona G., Sherrod, Stacy D., Aronoff, David M., McLean, John A., Gaddy, Jennifer A., Townsend, Steven D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078465/
https://ncbi.nlm.nih.gov/pubmed/32184236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00076-20
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