Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle

Defining the pathways that control cardiac development facilitates understanding the pathogenesis of congenital heart disease. Herein, we identify enrichment of a Cullin5 Ub ligase key subunit, Asb2, in myocardial progenitors and differentiated cardiomyocytes. Using two conditional murine knockouts,...

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Udgivet i:iScience
Main Authors: Yamak, Abir, Hu, Dongjian, Mittal, Nikhil, Buikema, Jan W., Ditta, Sheraz, Lutz, Pierre G., Moog-Lutz, Christel, Ellinor, Patrick T., Domian, Ibrahim J.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078385/
https://ncbi.nlm.nih.gov/pubmed/32179481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100959
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