Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle

Defining the pathways that control cardiac development facilitates understanding the pathogenesis of congenital heart disease. Herein, we identify enrichment of a Cullin5 Ub ligase key subunit, Asb2, in myocardial progenitors and differentiated cardiomyocytes. Using two conditional murine knockouts,...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Yamak, Abir, Hu, Dongjian, Mittal, Nikhil, Buikema, Jan W., Ditta, Sheraz, Lutz, Pierre G., Moog-Lutz, Christel, Ellinor, Patrick T., Domian, Ibrahim J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078385/
https://ncbi.nlm.nih.gov/pubmed/32179481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100959
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