Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis

Although fibrosis depicts a reparative mechanism, maladaptation of the heart due to excessive production of extracellular matrix accelerates cardiac dysfunction. The anthraquinone Rhein was examined for its anti-fibrotic potency to mitigate cardiac fibroblast-to-myofibroblast transition (FMT). Prima...

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Publicado no:Sci Rep
Main Authors: Barbosa, David Monteiro, Fahlbusch, Pia, Herzfeld de Wiza, Daniella, Jacob, Sylvia, Kettel, Ulrike, Al-Hasani, Hadi, Krüger, Martina, Ouwens, D. Margriet, Hartwig, Sonja, Lehr, Stefan, Kotzka, Jorg, Knebel, Birgit
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078222/
https://ncbi.nlm.nih.gov/pubmed/32184434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61886-3
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