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Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation

Tremor is currently ranked as the most common movement disorder. The brain regions and neural signals that initiate the debilitating shakiness of different body parts remain unclear. Here, we found that genetically silencing cerebellar Purkinje cell output blocked tremor in mice that were given the...

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Pubblicato in:eLife
Autori principali: Brown, Amanda M, White, Joshua J, van der Heijden, Meike E, Zhou, Joy, Lin, Tao, Sillitoe, Roy V
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077982/
https://ncbi.nlm.nih.gov/pubmed/32180549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51928
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