Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is caused by pathogenic variants in sarcomere protein genes that evoke hypercontractility, poor relaxation, and increased energy consumption by the heart and increased patient risks for arrhythmias and heart failure. Recent studies show that pathogenic m...

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Bibliografiske detaljer
Udgivet i:Circulation
Main Authors: Toepfer, Christopher N., Garfinkel, Amanda C., Venturini, Gabriela, Wakimoto, Hiroko, Repetti, Giuliana, Alamo, Lorenzo, Sharma, Arun, Agarwal, Radhika, Ewoldt, Jourdan F., Cloonan, Paige, Letendre, Justin, Lun, Mingyue, Olivotto, Iacopo, Colan, Steve, Ashley, Euan, Jacoby, Daniel, Michels, Michelle, Redwood, Charles S., Watkins, Hugh C., Day, Sharlene M., Staples, James F., Padrón, Raúl, Chopra, Anant, Ho, Carolyn Y., Chen, Christopher S., Pereira, Alexandre C., Seidman, Jonathan G., Seidman, Christine E.
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2020
Fag:
Original Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077965/
https://ncbi.nlm.nih.gov/pubmed/31983222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.042339
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