Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures

Proteasomes are highly abundant and conserved protease complexes that eliminate unwanted proteins in the cells. As a single-chain ATP-independent nuclear proteasome activator, proteasome activator 200 (PA200) associates with 20S core particle to form proteasome complex that catalyzes polyubiquitin-i...

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發表在:PLoS Biol
Main Authors: Guan, Hongxin, Wang, Youwang, Yu, Ting, Huang, Yini, Li, Mianhuan, Saeed, Abdullah F. U. H., Perčulija, Vanja, Li, Daliang, Xiao, Jia, Wang, Dongmei, Zhu, Ping, Ouyang, Songying
格式: Artigo
語言:Inglês
出版: Public Library of Science 2020
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077846/
https://ncbi.nlm.nih.gov/pubmed/32134919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000654
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