Infantile restrictive cardiomyopathy: cTnI-R170G/W impair the interplay of sarcomeric proteins and the integrity of thin filaments

TNNI3 encoding cTnI, the inhibitory subunit of the troponin complex, is the main target for mutations leading to restrictive cardiomyopathy (RCM). Here we investigate two cTnI-R170G/W amino acid replacements, identified in infantile RCM patients, which are located in the regulatory C-terminus of cTn...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cimiotti, Diana, Fujita-Becker, Setsuko, Möhner, Desirée, Smolina, Natalia, Budde, Heidi, Wies, Aline, Morgenstern, Lisa, Gudkova, Alexandra, Sejersen, Thomas, Sjöberg, Gunnar, Mügge, Andreas, Nowaczyk, Marc M., Reusch, Peter, Pfitzer, Gabriele, Stehle, Robert, Schröder, Rasmus R., Mannherz, Hans G., Kostareva, Anna, Jaquet, Kornelia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077804/
https://ncbi.nlm.nih.gov/pubmed/32182250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0229227
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