Pentamidine niosomes thwart S100B effects in human colon carcinoma biopsies favouring wtp53 rescue

S100B protein bridges chronic mucosal inflammation and colorectal cancer given its ability to activate NF‐kappaB transcription via RAGE signalling and sequestrate pro‐apoptotic wtp53. Being an S100B inhibitor, pentamidine antagonizes S100B‐wtp53 interaction, restoring wtp53‐mediated pro‐apoptotic co...

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Bibliografiske detaljer
Udgivet i:J Cell Mol Med
Main Authors: Seguella, Luisa, Rinaldi, Federica, Marianecci, Carlotta, Capuano, Riccardo, Pesce, Mirella, Annunziata, Giuseppe, Casano, Fabrizio, Bassotti, Gabrio, Sidoni, Angelo, Milone, Marco, Aprea, Giovanni, de Palma, Giovanni Domenico, Carafa, Maria, Pesce, Marcella, Esposito, Giuseppe, Sarnelli, Giovanni
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077541/
https://ncbi.nlm.nih.gov/pubmed/32022398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14943
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