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HCC-derived EGFR mutants are functioning, EGF-dependent, and erlotinib-resistant
BACKGROUND: Epidermal growth factor receptor (EGFR) has emerged as an important therapeutic target. Overexpression of EGFR is frequently observed in hepatocellular carcinoma (HCC) and EGFR activation has been proven to be a potential determinant of primary resistance of HCC cells to sorafenib. In ou...
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| Veröffentlicht in: | Cell Biosci |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7076995/ https://ncbi.nlm.nih.gov/pubmed/32190291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-020-00407-1 |
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