The initiation of meiotic sex chromosome inactivation sequesters DNA damage signaling from autosomes in mouse spermatogenesis

Meiotic sex chromosome inactivation (MSCI) is an essential event in the mammalian male germline. MSCI is directed by a DNA damage response (DDR) pathway centered on the phosphorylation of histone variant H2AX at serine 139 (termed γH2AX). The failure to initiate MSCI is linked to complete meiotic ar...

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Udgivet i:Curr Biol
Main Authors: Abe, Hironori, Alavattam, Kris G., Hu, Yueh-Chiang, Pang, Qishen, Andreassen, Paul R., Hegde, Rashmi S., Namekawa, Satoshi H.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076562/
https://ncbi.nlm.nih.gov/pubmed/31902729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2019.11.064
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