Synthesis and Characterization of pH-Responsive PEG-Poly(β-Amino Ester) Block Copolymer Micelles as Drug Carriers to Eliminate Cancer Stem Cells

PEG-poly(β-amino ester) (PEG-PBAE), which is an effective pH-responsive copolymer, was mainly synthesized by Michael step polymerization. Thioridazine (Thz), which was reported to selectively eliminate cancer stem cells (CSCs), was loaded into PEG-PBAE micelles (PPM) prepared by self-assembly at low...

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Veröffentlicht in:Pharmaceutics
Hauptverfasser: Li, Weinan, Sun, Jialin, Zhang, Xiaoyu, Jia, Li, Qiao, Mingxi, Zhao, Xiuli, Hu, Haiyang, Chen, Dawei, Wang, Yanhong
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076537/
https://ncbi.nlm.nih.gov/pubmed/32019122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12020111
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