Targeting Small Molecule Delivery to the Brain and Spinal Cord via Intranasal Administration of Rabies Virus Glycoprotein (RVG29)-Modified PLGA Nanoparticles

Alternative routes of administration are one approach that could be used to bypass the blood–brain barrier (BBB) for effective drug delivery to the central nervous system (CNS). Here, we focused on intranasal delivery of polymer nanoparticles. We hypothesized that surface modification of poly(lactic...

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Veröffentlicht in:Pharmaceutics
Hauptverfasser: Chung, Eugene P., Cotter, Jennifer D., Prakapenka, Alesia V., Cook, Rebecca L., DiPerna, Danielle M., Sirianni, Rachael W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076461/
https://ncbi.nlm.nih.gov/pubmed/31991664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12020093
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