Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease

Parkinson's disease (PD) is a multifactorial malady and the second most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in the midbrain. A hallmark of PD pathology is the formation of intracellular protein inclusions, termed Lewy bodies (LBs). Recent MS studies...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Kumari, Raniki, Kumar, Roshan, Kumar, Sanjay, Singh, Abhishek Kumar, Hanpude, Pranita, Jangir, Deepak, Maiti, Tushar Kanti
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076217/
https://ncbi.nlm.nih.gov/pubmed/32005664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009546
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