Processing and integration of functionally oriented prespacers in the Escherichia coli CRISPR system depends on bacterial host exonucleases

CRISPR-Cas systems provide bacteria with adaptive immunity against viruses. During spacer adaptation, the Cas1-Cas2 complex selects fragments of foreign DNA, called prespacers, and integrates them into CRISPR arrays in an orientation that provides functional immunity. Cas4 is involved in both the tr...

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Vydáno v:J Biol Chem
Hlavní autoři: Ramachandran, Anita, Summerville, Lesley, Learn, Brian A., DeBell, Lily, Bailey, Scott
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076208/
https://ncbi.nlm.nih.gov/pubmed/31914418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012196
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