SLAMF6​ deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint

SLAMF6 is a homotypic receptor of the Ig-superfamily whose exact role in immune modulation has remained elusive. Its constitutive expression on resting and activated T cells precludes it from being a bona fide exhaustion marker. By breeding Pmel-1 mice with SLAMF6 -/- mice, we generated donors for T...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Hajaj, Emma, Eisenberg, Galit, Klein, Shiri, Frankenburg, Shoshana, Merims, Sharon, Ben David, Inna, Eisenhaure, Thomas, Henrickson, Sarah E, Villani, Alexandra Chloé, Hacohen, Nir, Abudi, Nathalie, Abramovich, Rinat, Cohen, Jonathan E, Peretz, Tamar, Veillette, Andre, Lotem, Michal
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Human Biology and Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075692/
https://ncbi.nlm.nih.gov/pubmed/32122464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52539
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