rAAV-Mediated Cochlear Gene Therapy: Prospects and Challenges for Clinical Application

Over the last decade, pioneering molecular gene therapy for inner-ear disorders have achieved experimental hearing improvements after a single local or systemic injection of adeno-associated, virus-derived vectors (rAAV for recombinant AAV) encoding an extra copy of a normal gene, or ribozymes used...

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Bibliographic Details
Published in:J Clin Med
Main Authors: Blanc, Fabian, Mondain, Michel, Bemelmans, Alexis-Pierre, Affortit, Corentin, Puel, Jean-Luc, Wang, Jing
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073754/
https://ncbi.nlm.nih.gov/pubmed/32098144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm9020589
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