Increased Tumor Penetration of Single-Domain Antibody Drug Conjugates Improves In Vivo Efficacy in Prostate Cancer Models

Targeted delivery of chemotherapeutics aims to increase efficacy and lower toxicity by concentrating drugs at the site-of-action, a method embodied by the seven current FDA approved antibody-drug conjugates (ADCs). However, a variety of pharmacokinetic challenges result in relatively narrow therapeu...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Nessler, Ian, Khera, Eshita, Vance, Steven, Kopp, Anna, Qiu, Qifeng, Keating, Thomas A., Abu-Yousif, Adnan O., Sandal, Thomas, Legg, James, Thompson, Lorraine, Goodwin, Normann, Thurber, Greg M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073300/
https://ncbi.nlm.nih.gov/pubmed/31941698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-2295
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