A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro

TFEB (transcription factor EB), which is a master regulator of autophagy and lysosome biogenesis, is considered to be a new therapeutic target for Parkinson’s disease (PD). However, only several small-molecule TFEB activators have been discovered and their neuroprotective effects in PD are unclear....

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Wang, Ziying, Yang, Chuanbin, Liu, Jia, Chun-Kit Tong, Benjamin, Zhu, Zhou, Malampati, Sandeep, Gopalkrishnashetty Sreenivasmurthy, Sravan, Cheung, King-Ho, Iyaswamy, Ashok, Su, Chengfu, Lu, Jiahong, Song, Juxian, Li, Min
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073207/
https://ncbi.nlm.nih.gov/pubmed/32098449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21041515
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