Galectin 3 Deficiency Alters Chondrocyte Primary Cilium Formation and Exacerbates Cartilage Destruction via Mitochondrial Apoptosis

Mechanical overload and aging are the main risk factors of osteoarthritis (OA). Galectin 3 (GAL3) is important in the formation of primary cilia, organelles that are able to sense mechanical stress. The objectives were to evaluate the role of GAL3 in chondrocyte primary cilium formation and in OA in...

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Pubblicato in:Int J Mol Sci
Autori principali: Hafsia, Narjès, Forien, Marine, Renaudin, Félix, Delacour, Delphine, Reboul, Pascal, Van Lent, Peter, Cohen-Solal, Martine, Lioté, Frédéric, Poirier, Françoise, Ea, Hang Korng
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073077/
https://ncbi.nlm.nih.gov/pubmed/32098291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21041486
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