Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain

Konjac ceramide (kCer) is a plant-type ceramide composed of various long-chain bases and α-hydroxyl fatty acids. The presence of d4t,8t-sphingadienine is essential for semaphorin 3A (Sema3A)-like activity. Herein, we examined the three neuropilin 1 (Nrp1) domains (a1a2, b1b2, or c), and found that a...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Usuki, Seigo, Yasutake, Yoshiaki, Tamura, Noriko, Tamura, Tomohiro, Tanji, Kunikazu, Saitoh, Takashi, Murai, Yuta, Mikami, Daisuke, Yuyama, Kohei, Monde, Kenji, Mukai, Katsuyuki, Igarashi, Yasuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072815/
https://ncbi.nlm.nih.gov/pubmed/32102436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9020517
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