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Poison-Exon Inclusion in DHX9 Reduces Its Expression and Sensitizes Ewing Sarcoma Cells to Chemotherapeutic Treatment

Alternative splicing is a combinatorial mechanism by which exons are joined to produce multiple mRNA variants, thus expanding the coding potential and plasticity of eukaryotic genomes. Defects in alternative splicing regulation are associated with several human diseases, including cancer. Ewing sarc...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Palombo, Ramona, Verdile, Veronica, Paronetto, Maria Paola
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072589/
https://ncbi.nlm.nih.gov/pubmed/32023846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9020328
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