Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy

Lysosomal accumulation of sunitinib has been suggested as an underlying mechanism of resistance. Here, we investigated if photochemical internalization (PCI), a technology for cytosolic release of drugs entrapped in endosomes and lysosomes, would activate lysosomal sequestered sunitinib. By super-re...

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Publicat a:Cancers (Basel)
Autors principals: Wong, Judith Jing Wen, Berstad, Maria Brandal, Fremstedal, Ane Sofie Viset, Berg, Kristian, Patzke, Sebastian, Sørensen, Vigdis, Peng, Qian, Selbo, Pål Kristian, Weyergang, Anette
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072415/
https://ncbi.nlm.nih.gov/pubmed/32053965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020417
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