Melanoma-Derived Exosomal miR-125b-5p Educates Tumor Associated Macrophages (TAMs) by Targeting Lysosomal Acid Lipase A (LIPA)

Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment, promoting tumor initiation, growth, progression, metastasis, and immune evasion. Recently it was shown that cancer cell-derived exosomes induce a tumor-promoting phenotype in TAMs. Exosome-loaded pr...

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Publicado en:Cancers (Basel)
Autores principales: Gerloff, Dennis, Lützkendorf, Jana, Moritz, Rose K.C., Wersig, Tom, Mäder, Karsten, Müller, Lutz P., Sunderkötter, Cord
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072270/
https://ncbi.nlm.nih.gov/pubmed/32079286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020464
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