Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b(+) cDCs Promotes Pulmonary Tolerance through Downregulation of CD40

Activation of the C5/C5a/C5a receptor 1 (C5aR1) axis during allergen sensitization protects from maladaptive T cell activation. To explore the underlying regulatory mechanisms, we analyzed the impact of C5aR1 activation on pulmonary CD11b(+) conventional dendritic cells (cDCs) in the context of hous...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Antoniou, Konstantina, Ender, Fanny, Vollbrandt, Tillman, Laumonnier, Yves, Rathmann, Franziska, Pasare, Chandrashekhar, Singh, Harinder, Köhl, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072238/
https://ncbi.nlm.nih.gov/pubmed/31991941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9020300
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