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Short and simple sequences favored the emergence of N-helix phospho-ligand binding sites in the first enzymes
The ubiquity of phospho-ligands suggests that phosphate binding emerged at the earliest stage of protein evolution. To evaluate this hypothesis and unravel its details, we identified all phosphate-binding protein lineages in the Evolutionary Classification of Protein Domains database. We found at le...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7071883/ https://ncbi.nlm.nih.gov/pubmed/32079722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911742117 |
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