Autophagy-mediated occludin degradation contributes to blood–brain barrier disruption during ischemia in bEnd.3 brain endothelial cells and rat ischemic stroke models

BACKGROUND: The blood–brain barrier (BBB) maintains homeostasis of the brain environment by tightly regulating the entry of substances from systemic circulation. A breach in the BBB results in increased permeability to potentially toxic substances and is an important contributor to amplification of...

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Publicado en:Fluids Barriers CNS
Autores principales: Kim, Kyeong-A, Kim, Donghyun, Kim, Jeong-Hyeon, Shin, Young-Jun, Kim, Eun-Sun, Akram, Muhammad, Kim, Eun-Hye, Majid, Arshad, Baek, Seung-Hoon, Bae, Ok-Nam
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071658/
https://ncbi.nlm.nih.gov/pubmed/32169114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-020-00182-8
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