Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles

In this study, a novel series of 1,2-disubstituted benzo[d]imidazoles was rationally designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. Our design strategy is two-fold; it aimed first at studying the effect of replacing the 5-methylfuryl moiety of the well-known antiangiogenic 2-fury...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Abdel-Mohsen, Heba T., Abdullaziz, Mona A., El Kerdawy, Ahmed M., Ragab, Fatma A. F., Flanagan, Keith J., Mahmoud, Abeer E. E., Ali, Mamdouh M., El Diwani, Hoda I., Senge, Mathias O.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071059/
https://ncbi.nlm.nih.gov/pubmed/32053964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25040770
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