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PNA Clamping in Nucleic Acid Amplification Protocols to Detect Single Nucleotide Mutations Related to Cancer

This review describes the application of peptide nucleic acids (PNAs) as clamps that prevent nucleic acid amplification of wild-type DNA so that DNA with mutations may be observed. These methods are useful to detect single-nucleotide polymorphisms (SNPs) in cases where there is a small amount of mut...

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Bibliografiske detaljer
Udgivet i:Molecules
Main Authors: Fouz, Munira F., Appella, Daniel H.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070360/
https://ncbi.nlm.nih.gov/pubmed/32059456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25040786
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