Usefulness of Peptide Nucleic Acid (PNA)-Clamp Smart Amplification Process Version 2 (SmartAmp2) for Clinical Diagnosis of KRAS Codon12 Mutations in Lung Adenocarcinoma: Comparison of PNA-Clamp SmartAmp2 and PCR-Related Methods

KRAS is an oncogene that can be activated by mutations. Patients with non-small cell lung cancer who have KRAS mutations do not respond to tyrosine kinase inhibitors; therefore, accurate detection of KRAS mutations is important for deciding therapeutic strategies. Although sequencing-related techniq...

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Detalhes bibliográficos
Main Authors: Araki, Takuya, Shimizu, Kimihiro, Nakamura, Katsunori, Nakamura, Tomonori, Mitani, Yasumasa, Obayashi, Kyoko, Fujita, Yukiyoshi, Kakegawa, Seiichi, Miyamae, Yohei, Kaira, Kyoichi, Ishidao, Takefumi, Lezhava, Alexander, Hayashizaki, Yoshihide, Takeyoshi, Izumi, Yamamoto, Koujirou
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797726/
https://ncbi.nlm.nih.gov/pubmed/20007840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2010.090081
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