Different receptor mechanisms underlying phytocannabinoid‐ versus synthetic cannabinoid‐induced tetrad effects: Opposite roles of CB(1)/CB(2) versus GPR55 receptors

BACKGROUND AND PURPOSE: Cannabis or cannabinoids produce characteristic tetrad effects—analgesia, hypothermia, catalepsy and suppressed locomotion, which are believed to be mediated by the activation of cannabinoid CB(1) receptors. Given recent findings of CB(2) and GPR55 receptors in the brain, we...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Wang, Xiao‐Fei, Galaj, Ewa, Bi, Guo‐Hua, Zhang, Cindy, He, Yi, Zhan, Jia, Bauman, Michael H., Gardner, Eliot L., Xi, Zheng‐Xiong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070166/
https://ncbi.nlm.nih.gov/pubmed/31877572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14958
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