An amber obligate active site-directed ligand evolution technique for phage display

Although noncanonical amino acids (ncAAs) were first incorporated into phage libraries through amber suppression nearly two decades ago, their application for use in drug discovery has been limited due to inherent library bias towards sense-containing phages. Here, we report a technique based on sup...

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Udgivet i:Nat Commun
Main Authors: Tharp, Jeffery M., Hampton, J. Trae, Reed, Catrina A., Ehnbom, Andreas, Chen, Peng-Hsun Chase, Morse, Jared S., Kurra, Yadagirri, Pérez, Lisa M., Xu, Shiqing, Liu, Wenshe Ray
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070036/
https://ncbi.nlm.nih.gov/pubmed/32170178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15057-7
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