An amber obligate active site-directed ligand evolution technique for phage display

Although noncanonical amino acids (ncAAs) were first incorporated into phage libraries through amber suppression nearly two decades ago, their application for use in drug discovery has been limited due to inherent library bias towards sense-containing phages. Here, we report a technique based on sup...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Tharp, Jeffery M., Hampton, J. Trae, Reed, Catrina A., Ehnbom, Andreas, Chen, Peng-Hsun Chase, Morse, Jared S., Kurra, Yadagirri, Pérez, Lisa M., Xu, Shiqing, Liu, Wenshe Ray
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070036/
https://ncbi.nlm.nih.gov/pubmed/32170178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15057-7
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