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The engineered anti-GPC3 immunotoxin, HN3-ABD-T20, produces regression in mouse liver cancer xenografts via prolonged serum retention
Treatment of hepatocellular carcinomas (HCC) using our glypican-3 (GPC3)-targeting human nanobody (HN3) immunotoxins causes potent tumor regression by blocking protein synthesis and down-regulating the Wnt signaling pathway. However, immunogenicity and a short serum half-life may limit the ability o...
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| Veröffentlicht in: | Hepatology |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7069773/ https://ncbi.nlm.nih.gov/pubmed/31520528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30949 |
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