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Multigram-scale flow synthesis of the chiral key intermediate of (–)-paroxetine enabled by solvent-free heterogeneous organocatalysis
The catalytic enantioselective synthesis of the chiral key intermediate of the antidepressant (–)-paroxetine is demonstrated as a continuous flow process on multi-gram scale. The critical step is a solvent-free organocatalytic conjugate addition followed by a telescoped reductive amination–lactamiza...
Gorde:
| Argitaratua izan da: | Chem Sci |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Royal Society of Chemistry
2019
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7069365/ https://ncbi.nlm.nih.gov/pubmed/32206263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc04752b |
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