In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3

Acid-sensing ion channels (ASICs) are voltage-independent cation channels that detect decreases in extracellular pH. Dysregulation of ASICs underpins a number of pathologies. Of particular interest is ASIC3, which is recognised as a key sensor of acid-induced pain and is important in the establishme...

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Publicado no:Biochem Pharmacol
Main Authors: Callejo, Gerard, Pattison, Luke A., Greenhalgh, Jack C., Chakrabarti, Sampurna, Andreopoulou, Evangelia, Hockley, James R.F., Smith, Ewan St. John, Rahman, Taufiq
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068650/
https://ncbi.nlm.nih.gov/pubmed/32027884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2020.113834
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