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Amiloride and GMQ Allosteric Modulation of the GABA-A ρ1 Receptor: Influences of the Intersubunit Site

Amiloride, a diuretic used in the treatment of hypertension and congestive heart failure, and 2-guanidine-4-methylquinazoline (GMQ) are guanidine compounds that modulate acid-sensing ion channels. Both compounds have demonstrated affinity for a variety of membrane proteins, including members of the...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Snell, Heather D., Gonzales, Eric B.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429676/
https://ncbi.nlm.nih.gov/pubmed/25829529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.222802
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