Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours

Immune checkpoint blockade (ICB)-based or natural cancer immune responses largely eliminate tumours. Yet, they require additional mechanisms to arrest those cancer cells that are not rejected. Cytokine-induced senescence (CIS) can stably arrest cancer cells, suggesting that interferon-dependent indu...

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Argitaratua izan da:Nat Commun
Egile Nagusiak: Brenner, Ellen, Schörg, Barbara F., Ahmetlić, Fatima, Wieder, Thomas, Hilke, Franz Joachim, Simon, Nadine, Schroeder, Christopher, Demidov, German, Riedel, Tanja, Fehrenbacher, Birgit, Schaller, Martin, Forschner, Andrea, Eigentler, Thomas, Niessner, Heike, Sinnberg, Tobias, Böhm, Katharina S., Hömberg, Nadine, Braumüller, Heidi, Dauch, Daniel, Zwirner, Stefan, Zender, Lars, Sonanini, Dominik, Geishauser, Albert, Bauer, Jürgen, Eichner, Martin, Jarick, Katja J., Beilhack, Andreas, Biskup, Saskia, Döcker, Dennis, Schadendorf, Dirk, Quintanilla-Martinez, Leticia, Pichler, Bernd J., Kneilling, Manfred, Mocikat, Ralph, Röcken, Martin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
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Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7067802/
https://ncbi.nlm.nih.gov/pubmed/32165639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14987-6
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