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Extrapolation of Drug Clearance in Children ≤ 2 Years of Age from Empirical Models Using Data from Children (> 2 Years) and Adults

BACKGROUND: The application of modeling and simulation approaches in clinical pharmacology studies has gained momentum over the last 20 years. OBJECTIVES: The objective of this study was to develop six empirical models from clearance data obtained from children aged > 2 years and adults to evalua...

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Bibliografiske detaljer
Udgivet i:Drugs R D
Hovedforfatter: Mahmood, Iftekhar
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7067721/
https://ncbi.nlm.nih.gov/pubmed/31820365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40268-019-00291-2
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