Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates

Infections by multidrug-resistant Gram-negative bacteria are increasingly common, prompting the renewed interest in the use of colistin. Colistin specifically targets Gram-negative bacteria by interacting with the anionic lipid A moieties of lipopolysaccharides, leading to membrane destabilization a...

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Veröffentlicht in:mSphere
Hauptverfasser: Janssen, Axel B., Bartholomew, Toby L., Marciszewska, Natalia P., Bonten, Marc J. M., Willems, Rob J. L., Bengoechea, Jose A., van Schaik, Willem
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7067592/
https://ncbi.nlm.nih.gov/pubmed/32161146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00143-20
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