Evolution of Colistin Resistance in the Klebsiella pneumoniae Complex Follows Multiple Evolutionary Trajectories with Variable Effects on Fitness and Virulence Characteristics

The increasing prevalence of multidrug-resistant Klebsiella pneumoniae has led to a resurgence in the use of colistin as a last-resort drug. Colistin is a cationic antibiotic that selectively acts on Gram-negative bacteria through electrostatic interactions with anionic phosphate groups of the lipid...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Janssen, Axel B., Doorduijn, Dennis J., Mills, Grant, Rogers, Malbert R. C., Bonten, Marc J. M., Rooijakkers, Suzan H. M., Willems, Rob J. L., Bengoechea, Jose A., van Schaik, Willem
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927857/
https://ncbi.nlm.nih.gov/pubmed/33139278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01958-20
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