ATR expands embryonic stem cell fate potential in response to replication stress

Unrepaired DNA damage during embryonic development can be potentially inherited by a large population of cells. However, the quality control mechanisms that minimize the contribution of damaged cells to developing embryos remain poorly understood. Here, we uncovered an ATR- and CHK1-mediated transcr...

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Vydáno v:eLife
Hlavní autoři: Atashpaz, Sina, Samadi Shams, Sara, Gonzalez, Javier Martin, Sebestyén, Endre, Arghavanifard, Negar, Gnocchi, Andrea, Albers, Eliene, Minardi, Simone, Faga, Giovanni, Soffientini, Paolo, Allievi, Elisa, Cancila, Valeria, Bachi, Angela, Fernández-Capetillo, Óscar, Tripodo, Claudio, Ferrari, Francesco, López-Contreras, Andrés Joaquin, Costanzo, Vincenzo
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7067586/
https://ncbi.nlm.nih.gov/pubmed/32163370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54756
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