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Knocking-out the Siah2 E3 ubiquitin ligase prevents mitochondrial NCX3 degradation, regulates mitochondrial fission and fusion, and restores mitochondrial function in hypoxic neurons
BACKGROUND: Na(+)/Ca(2)(+) exchanger isoform 3 (NCX3) regulates mitochondrial Ca(2+) handling through the outer mitochondrial membrane (OMM) and promotes neuronal survival during oxygen and glucose deprivation (OGD). Conversely, Seven In-Absentia Homolog 2 (Siah2), an E3-ubiquitin ligase, which is a...
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| Pubblicato in: | Cell Commun Signal |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7066748/ https://ncbi.nlm.nih.gov/pubmed/32164721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-0529-x |
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