Molecular Modeling Study of Uncharged Oximes Compared to HI-6 and 2-PAM Inside Human AChE Sarin and VX Conjugates

[Image: see text] The deleterious effects of nerve agents over the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) turned these compounds into the most dangerous chemical weapons known. Among the antidotes in use today against these agents, oximes in combination with other drugs...

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Veröffentlicht in:ACS Omega
Hauptverfasser: Souza, Felipe Rodrigues de, Rodrigues Garcia, Danielle, Cuya, Teobaldo, Pimentel, André Silva, Gonçalves, Arlan da Silva, Alencastro, Ricardo Bicca de, França, Tanos Celmar Costa
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066550/
https://ncbi.nlm.nih.gov/pubmed/32175496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b03737
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